Hiram Chase is a well liked Reverend in a small ministry in Utica. When his mental and physical health deteriorates, he is taken to Utica lunatic asylum. After his stay in the asylum, Hiram documents his experiences and those of other patients in the asylum. He describes his daily routine and the negative experiences he had, along with praising certain individuals whom he met during his "Two Years and Four Months in a Lunatic Asylum".